El estres se reconoce como un proceso fisiopatologico que ocurre cuando un individuo se enfrenta a demandas ambientales que sobrepasan sus recursos, haciendo que el cuerpo emita una respuesta, la cual implica la activacion fisiologica y cognitiva del cuerpo, (sistema nervioso central, sistema endocrino y sistema inmunologico), para actuar de manera mas rapida y energica a las exigencias dela situacion, por lo tanto esta respuesta es de naturaleza sistemica y trae una serie de consecuencias metabolicas tales como aumento de la sintesis de esteroides y un estado de inflamacion cronica,por lo que el estres psicologico se considera un factor de riesgo para el desarrollo de enfermedades cronicas. El estres psicologico en un campo academico, se denomina estres academico. Abstract: Stress is recognized as a pathophysiological process that occurs when an individual is faced with environmental demands that exceed their resources, making the body emits a stress response. This response involves the activation of physiological and cognitive body (central nervous system, endocrine system and immune system), to act faster and more energetic the situation so demands, thus this response is systemic in nature and brings a series of metabolic consequences such as increased steroid synthesis and a state of chronic inflammation, so that psychological stress is considered a risk factor for the development of chronic diseases. Psychological stress in an academic field, is called academic stress. Medical students are exposed to a greater number of stressors, which are inherentin his career, and predisposes them to have different levels of stress. Key words: Academic stress, psycho-neuro-endocrine-immunology, inflammation, C reactive protein.