The odontogenic infections arise from periapical or periodontal infections and can spread through the subcutaneous tissue giving rise to a cellulitis or abscess. On rare occasions these infections become severe and can involve the patient’s health. Microorganisms frequently isolated from these infections are Streptococcus viridans, Peptostreptococcus, Prevotella, Porphyromonas and Fusobacterium. The management of odontogenic infections should be determined based on the severity of the infection, and host’s immune status. Elimination of the cause by means of drainage and administration of the appropriate antibiotic usually suffices. Commonly used antibiotics are penicillins, cephalosporins, macrolides, clindamycin and metronidazole.