Background: More than 50 % of all drugs are prescribed, discharged, or sold wrongly, which exposes patients to unnecessary risks and favors the development of Surgical Site Infection (SSI) that is one of the most common complications in oral surgery. Adequate systemic antibiotic prescription helps to reduce the risk of SSI. Objective: Evaluate the pertinence of antibiotic prescription to prevent SSI by using the information registered on the medical records of patients who underwent dental extractions, surgical extractions, and soft tissue biopsies at the Oral and Maxillofacial Unit from the Barrios Unidos Hospital-Mederi. Method: From a population of 600 medical records, a sample of 234 medical records of patients who fulfill the inclusion criteria was calculated. Information about demographics, prescription, morbidity, and risk factors to develop SSI data was recorded. Results: Pertinence of antibiotics prescribed in relation to the studied procedures was of 10.26 %, considering that its indication is not taken into account. The proportion of SSI was of 4.7 %, which is similar to other reports. Conclusions: Abuse in antibiotic prescription with unjustified indications could prompt adverse effects because it focuses on already existing infectious processes and not on preventing them as it is recommended in the literature.