Transformation processes are conceptualized by all schools of therapy because they give meaning to their experience, draw boundaries and define the roles of those involved in it. When studied in the framework of a training program in systemic therapy, transformation processes give feed back to its objectives, methodology and provides knowledge to teachers and students. Therefore this study finds its justification in the need to document and explain the transformation processes that are generated in the therapeutic process, interactional dynamics and consultants, from self-reference processes of learning of the therapist. This was a qualitative research involved a case study of three therapeutic processes and the methodology used was the research-intervention and collaborative approach to research. The results show that the therapist and the consultants had similar self-referential changes that show a discontinuous rupture with their previous structure, which correspond to a second-order change, and with processes of differentiation and individuation. The therapeutic processes became more complex and productive to the extent that the therapist’s appropriation of the theory was accomplished and integrated with circular logic. Interactional dynamics became increasingly reciprocal when the therapist learned to recognize their emotions and when she had a connection with and the theory and herself. Finally, the study showed the recursive interaction between the levels of observation considered.