As a starting point, the current state of technology-based PYMES, which are addressed from an approach which show that occupy understaffed and its products, goods or services achieve a high value is set; Likewise, the current focus of SMEs technological base is viewed from its features, but neglect knowledge management and how to apply the great advantages that you have an appropriate way to generate innovation applied to managerial handling. It also seeks to identify the general characteristics and describe the main barriers of technology-based company of biotechnology, telecommunications and electronics sectors, assuming that these companies achieved a high proficiency in technical and scientific capabilities, closely related to the sector in which are, but neglect fundamentals and pillars in an organization.