Abstract This article presents the cases of four adult patients with three varieties of Kaposi’s sarcoma: epidemic, asso -FLDWHGZLWKKXPDQLPPXQRGH?FLHQF\YLUXVLQIHFWLRQV LDWURJHQLFDVVRFLDWHGZLWKFKURQLFLPPXQHVXSSUHVVLRQ DQGLQWKLVFDVHLQDPDQZLWKDOFRKROLFFLUUKRVLV DQGFODVVLFRFFXUULQJLQHOGHUO\SDWLHQWZLWKRXWSUHYLRXVO\NQRZQLPPXQRVXSSUHVVLRQ$OOIRXUFDVHVKDGJDVWURLQWHVWLQDOLQYROYHPHQW$EULHIUHYLHZRIWKHGLVHDVHLVincluded. Keywords .DSRVL¶VVDUFRPDVDUFRPDJDVWURLQWHVWLQDOFRPSURPLVR Case report INTRODUCTION Kaposi’s sarcoma (KS) is a complex malignant tumor of mesenchymal origin which is associated with human her-pes virus 8 (KSHV). It normally coincides with an immune disorder that promotes an environment that is ideal for its development (1, 2). There are four types of KS: classical, endemic, African and iatrogenic. The endemic and African types have specific racial and geographic distributions, are more benign, and are associated with HIV/AIDS. To date, iatrogenic KS has been described in close association with immunosuppression used with transplantation and has the worst prognosis. The most common location of KS is in the skin. The second most common is in lymph nodes, and in third place is the gastrointestinal tract. Endoscopic indications vary from ulcers to purple nodular submucosal lesions. The most important histological indications are vascular proliferation characterized by the presence of vas-cular slits, extravasation of erythrocytes with hemosiderin deposits, and immunohistochemistry that is positive for herpes virus-8 (1-5).