Abstract Typhoid fever is a systemic infection caused by Salmonella enterica serotype Typhi as the result of ingestion of contaminated food (fecal-oral). It is a public health problem, especially in developing countries where it is very prevalent and where it is related to poor sanitation. Hepatitis occurs in 1% to 26% of patients with typhoid, VRW\SKRLGIHYHUVKRXOGEHVXVSHFWHGZKHQMDXQGLFHIHYHUDQGKHSDWLWLVFRH[LVW1HYHUWKHOHVVLWLVGLI?FXOWto distinguish it from hepatotropic hepatitis virus. The key to diagnosis is that fever disappears in these viral infections while the patient still has jaundice. Final diagnosis requires the isolation of salmonella through blood and/or cultures, but most importantly cultures of bone marrow which have the highest diagnostic yield. Keywords Hepatitis, salmonella, enteric fever. Review articles INTRODUCTION There are slight variations in the liver function profile in 21% to 60% of cases of patients with typhoid fever (1). However, acute hepatitis does not occur very frequently and has only been reported in 1% to 26% of patients (1-3). When present, it is a frequent cause of recurrence of the disease (2, 4). Although clinical manifestations of hepatitis are indistinguishable from viral hepatitis due to hepatotro-pic viruses (A, B, C, D, E), the diagnosis may be suspected when a patient has fever, jaundice, and hepatitis (increased transaminases) simultaneously. When jaundice appears in patients with hepatitis due to those viruses, the general symptoms including fever disappear (2,4-6). In such cases, we must also rule out other causes such as yellow fever, dengue, chickenpox, and malaria (2, 6). In addition to the coexistence of fever with jaundice and hepatitis, the cha-racteristics of typhoid fever