Summary Introduction and aims: Until recently the most useful tools designed for evaluating the small intestine were the endoscopic capsule and double balloon enteroscopy. However, the search for a safer, faster, less compli-cated technique has led to the development of the single balloon enteroscopy system. This paper presents our experience with this technique in the Hospital Cardiovascular del Nino in Cundinamarca (Soacha-Colombia) along with a brief review of the most important aspects of performing this procedure. Patients and Methods: Between January 15, 2009 and February 15, 2009 a prospective study was con-ducted on 29 patients at the Hospital Cardiovascular ‘El nino’. A total of 41 single balloon enteroscopies were performed on these patients. Indications, times of procedures, fi ndings and complications were studied in all of these patients. Results: Average diagnostic time was 28.5 minutes with 71 minutes of total procedure time. Total explo-rations using mixed approaches were performed on two patients (16%). Findings included foreign bodies, angiodysplasias, Crohn’s disease, Peutz-Jeghers Syndrome, vasculitis, nodular lymphoid hyperplasia, in-testinal varicose veins and neoplasias. Diagnostic yield for occult bleeding was 81%. No complications were registered.