Presentamos el caso de una mujer de 53 anos, diagnosticada y tratada inicialmente para esclerosis multiple, quien presento varias recaidas y serias secuelas motoras, visuales y de la sensibilidad. Se llevaron a cabo estudios paraclinicos donde se informo anticuerpos antiacuaporina 4 positivos, anticuerpos antinucleares 1/80, anticardiolipinas y virus linfotropico humano I y II negativos. Se presenta en reunion de casos clinicos del Departamento de Medicina Interna de la augusta Universidad del Cauca, se hace un replanteamiento del diagnostico y se concluye un sindrome de Devic. El sindrome de Devic, actualmente denominado Desordenes del Espectro de la neuromielitis optica, es un desorden autoinmune, inflamatorio y desmielinizante del sistema nervioso central, que afecta principalmente al nervio optico bilateral, el quiasma optico y la medula espinal. Puede coexistir, ademas, con manifestaciones de vasculitis tipo lupus eritematoso sistemico o sindrome de anticuerpos antifosfolipidos. Su principal diagnostico diferencial es justamente la esclerosis multiple. DEVIC’S DISEASE (OPTIC NEUROMYELITIS) ABSTRACT We report the case of a woman of 53 years, initially diagnosed and treated for multiple sclerosis, who presented several relapses and serious motor, visual and sensitivity sequels. Paraclinical studies were performed, they reported antibodies acuaporine 4 positive, antinuclear antibodies 1/80, anti-cardiolipin antibodies and human T-lymphotropic virus I and II negative. It comes in clinical cases meeting developed in the Department of Internal Medicine of the august Univesity of Cauca, a rethinking of the diagnosis, which it concludes Devic’s syndrome. The Devic’s syndrome, currently known as Optic neuromyelitis Spectrum Disorders, is an autoimmune disorder, inflammatory and demyelinating central nervous system that primarily affects the bilateral optic nerve, optic chiasm and spinal cord. It can also coexist with vasculitis manifestations of systemic lupus erythematosus or antiphospholipid antibodies syndrome. Its main differential diagnosis is just multiple sclerosis.