Introduction: Different kind of transient sensory deprivation had shown to modulate some human cerebral function and can be used to improve the rehabilitation of these functions. Interestingly, both the ischemic nerve block (INB) and transient visual deprivation (TVD) elicit short term plasticity through related mechanism; however, their combinatory effect has not been studied before. Objective: To test in a preliminary way if the combination of these deprivations, may to enhance their individuals effects in sensory human system. Methods: Previous informed consent and regarding Helsmsisky’s declaration, 9 normal subjects were studied before and after, 90 minutes of TVD, 30 minutes of INB and the combination of both interventions. Both somatosensory evoked potentials for electrical stimulation and tactile discrimination acuity were greater two hours after the INB-TVD combination. On the other hand, the individual interventions (INB and TVD, separately) did not show any significant effect. Conclusion: The present preliminary study, points toward the transient TVD in combination with INB, may to potentiate their individual plastic effects, on the human sensory system even more than the explained by such interventions. Salud UIS 2011; 43(1): 71 Keyword: Touch perception, neuronal plasticity, sensory deprivation, evoked potentials 1. Estudiante, Doctorado en Ciencias Biomedicas, Universidad Nacional, Bogota. 2. Profesora, Escuela de Enfermeria, UIS, Bucaramanga. 3. Mediciencias Research Group, Universidad Nacional, Bogota. Innovaciones en Ciencias de la Salud y de la Vida (IESV), Departamento de Fisica y Geologia, Universidad de Pamplona, Pamplona, Colombia. 4. Grupo de Investigacion Tomodache, Universidad Nacional de Colombia, Bogota, Colombia. Recibido: 1 de mayo de 2010 Aceptado: 30 de junio de 2010 Resumenes del Congreso