The main objective of this study is to carry out a preliminary approach to the examination of the relationship between drug use and the health problems in Colombia. It was used a questionnaire with 11 categories of diseases or syndromes (respiratory, skin, neurological, psychiatric, liver, self-inmune, cardiac, traumas and accidents, sexually transmitted genitalurinary and others), which was applied at 101 drug users between 15 and 64 years of age and 50 non-consumers between 20 and 84 years old. Four groups of disorders (psychiatric, neurologic, cardiac, and respiratory difficulties) were significant among drug users. Psychiatric disorders included panic attacks, excessive euphoria, general anxiety, discouragement, depression and hallucinations; neurological problems, increase or decrease of sensitivity, memory loss and motor difficulties. Only a heart problem (arrhythmias) and one respiratory (chronic cough) were significantly present. This study lays the groundwork for the future calculations of health-drugs attributable fractions.