Predicción del comportamiento hidrodinámico en el escalado de un reactor de tanque agitado para procesos aerobios, mediante CFD CFD prediction of hydrodynamic behavior in the scale up of a stirred tank reactor for aerobic processes
In this paper the effects of some empirical scale up criteria (Re y P/V) on hydrodynamics are analyzed by using CFD simulations (Computational Fluid Dynamics) in 0.050 and 0.500 m 3 stirred tank bioreactors. The effects of turbulence, rotating flow, bubbles breakage and coalescence were simulated by using the k-e, MRF (Multiple Reference Frame) and PBM (Population Balance Model), respectively. The P/V scale up criteria showed better similar hydrodynamics than Re scale up criteria with respect to the 0.050 m 3 reactor. However, the high power consumption and cellular damage due to turbulence in animal cell cultures could be disadvantages in large scale prototypes of bioreactors.
