is the main causal microorgan-ism of the tuberculosis, is nowadays a infectious agent who causes a grand mortal-ity in the world and Colombia. OBJECTIVE: To determinate the mayor morphologicalfindings (macro and microscopically) of the tuberculosis no AIDS related in autop-sies of the patients at the Hospital Universitario de Santander. MATERIALS ANDMETHODS: A prospective observational study was made, with a population thatcorresponds to the autopsy patients of the Hospital Universitario de Santander (729patients). RESULTS: The diagnosis of tuberculosis no AIDS related was found in10.66 % of the cases (82 necropsies), 46.34 % of them were exclusively located inthe lung, 29.96 % extrapulmonary and the 24.39 % had mixed localization. The organmost frequently involved was de lung 70.73 % followed by the pleura with 25.60 %,the kidney was the isolated organ most frequently compromised. Macroscopicallythe fibrocaseous tuberculosis witch cavitations were the most frequent form of thedisease which 51.72 %, followed by military tuberculosis. Histologically granulomaswhich are constituted by giant multinucleated cells Langhans type were found in allpatients. CONCLUSIONS: The tuberculosis no AIDS related is one of the principalcauses of mortality in autopsy patients in the Hospital Universitario de Santander,the lung was the most affected organ and the predominant histopathological patternwas the chronic granulomatous inflammation with central caseous necrosis.