The soursop (Annona muricata L.) is a perishable tropical fruit with high nutritional value. The aim of this work was to evaluate the sorption thermodynamics of soursop powders with maltodextrin (MD), obtained by different drying technologies, thus allowing understanding the mechanisms that govern this process. Adsorption isotherms of freeze dried (FD), spray drying (SD) and vacuum drying (VD) powders were determined at 20, 30, 40 and 50 °C by using the static gravimetric method. The results showed that the better fits the adsorption experimental data is the GAB model (R 2>0.9893). The influence of the drying system in the model parameters was also shown. The monolayer moisture values between 5.28 and 9.30% (kg water/kg d.s) were within the reported range for dehydrated food.