In recent years biofuels have been studied as a good alternative instead of fossil fuels. Jatropha curcas L oil (J. curcas) is a feedstock used to produce biodiesel which does not affect food security, has good yields and more advantages than traditional oils. Therefore, in this work, a conceptual design of a biodiesel production from J. curcas was developed by simulation, using HYSYS® software. A case study was proposed to produce biodiesel from 11000kg/h of Jatropha oil. Sequential stages of esterification and transesterification were studied due to high content of free fatty acid (FFA) in the oil. Thermodynamic data of the components was obtained from several models, which allowed to obtain a biofuel with high content