The aim of this work is to simulate and analyze an extractive distillation process (extractive distillation and recovery columns) for the separation of Tetrahydrofuran (THF)-Water azeotropic mixture using Aspen Plus® and Aspen Split simulators. Calculation of vapor liquid equilibrium of Tetrahydrofuran-Water-Entrainer system was done using the NRTL model, which binary interaction parameters were regressed using experimental data. A methodology for the study and selection of different candidate entrainers was followed, determining that the most suitable is glycerol. The solvent to feed molar ratio, reflux molar ratio, feed stage, feed solvent stage, and fe ed solvent temperature, were determined and their effects on the separation and the energy consumption in the two columns was studied.