This paper describes the results and conclusions of a research whose main objective was to assess and identify the relationship between psychosocial factors at work and the experience of work Engagement in a private health care institution of the city of Cali, Colombia. Participants were 111 workers involved in care and administrative positions. The Cuestionario de Factores de Riesgo Psicosocial Intralaboral (Ministerio de la Proteccion Social, 2010). [Psycho-social risk factors at work Questionnaire] [Ministry of Social Protection, 2010] and the Spanish version of the Utrecht Work Engagement Scale [UWES], developed by Shaufeli and Bakker (2003) were used. The total score in the assessment of Psychosocial Risk Factors at work for the entire organization showed a medium level of risk. The higher risk levels were found in the dimensions of emotional demands at work and performance feedback. In the assessment of work Engagement, high and average scores were found for the three domains of this construct (vigor, dedication, and absorption), showing statistically significant relationships with the psychosocial factors of Control over work, Rewards, and Leadership and Social Relationships. As a conclusion, this research showed statistically significant relationships between Psychosocial Factors and work Engagement. Therefore, the importance