Pain is an unpleasant sensory and emotional experience associated with tissue damage, actual or potential. Two causes of neuropathic pain include Complex Regional Pain Syndrome, CRPS and neuropathic pain-DNP. Pain affects cognitive function and motor functioning. Describing the functional and cognitive profile in patients with CRPS engine and DNP is the objective of this study. Descriptive study in six patients, three of them suffer from CRPS and the other three cope with DNP. Neuropsychological assessment and performance profile by International Classification of Functioning. Discussion: The SDRC and DNP have a structural and physiological deficit in central and peripheral pain networks, limitation in functions of involved limbs, restrictions in the activities, and participation of different levels. As a chronic disease, pain affects cognitive and emotional function of the sufferer, due to different brain structures are affected because its presence.