After an exhaustive bibliographic analysis of how the different discoveries of false positive serology, the structure of cardiolipins and lupus anticoagulant were made, we will describe in a very succinct way the clinical findings and the findings of the laboratory studies, which were basting the group of clinical and laboratory researchers led by Graham Hughes at St. Thomas Hospital, until the early 1990s, and we will conclude this second part with the organization of forums, conferences, and workshops. When reviewing some of these proto-articles, it cannot be ruled out that some cases were antiphospholipid syndrome, but it is striking that the description of this syndrome was the product of a series of observations that were made in the clinical rounds of Saint Thomas Hospital from London in the group led by Graham Hughes, in more than a decade of clinical and laboratory analysis in a subgroup of patients with lupus and hematological manifestations, especially of the thrombophilic type and essentially the description of the primary form of the syndrome