Introduction: The Tumaco-Tolita culture occupied the geo-historic region of the Pacific Colombo-Ecuadorian coast from 300 BC to -600 AD. This culture was characterized for capturing with impressive realism the different pathologies that suffered their population, as well as evidence of genetic illnesses, congenital malformations, and processes of aging and death. Objective: To describe the evidences of neurological illnesses, and mainly the ones related to facial paralysis in the ceramic of the Tumaco-Tolita culture in the Universidad del Valle Museum «Julio Cesar Cubillos» at Cali, Colombia. Methods: The collection pieces of the Tumaco-Tolita culture of the Universidad de Valle archaeological museum «Julio Cesar Cubillos», were examined by a geneticist physician, a physician trained in the area of medical genetics, and an archaeologist. Cases with evidences of neurological illnesses and mainly facial paralyses were documented. Results: Out of the 500 examined pieces, 6 were found with clear evidence of facial paralysis, and out of them, the 3 that better showed this pathology were chosen. Conclusions: The Tumaco-Tolita culture represented facial paralyses in their ceramics, constituting one of the first registries of these conditions in the American pre-Columbian cultures.