This research seeks to develop some conceptual foundations for understanding the nature and characteristics of the professional knowledge of the Professor of chemistry in initial training, based on an analysis of pedagogic and didactic knowledge acquired and developed through his immersion in the faculties of science and education of the country educational realities, as well as their educational experiences gained in its first years of labour academic exercise; in this way, we believe that it is possible to plan professional development for its continuous improvement strategies favoring the development of self-regulatory and critical reflection on practice skills to address, address and overcome common problems with which we are in the exercise of our activities as teachers, recognizing, evaluating, and improving our performance continuously and gradually. Therefore a qualitative research of hermeneutic type is set, divided into two phases: the first, which will be a review and full understanding of the problem under study, and the second which applies a methodological strategy and interpreted the results. All with the purpose of promoting and teaching changes of teachers in initial training from the recognition and self-regulation of their professional knowledge.