This contribution discusses the primary German-speaking scientific travelers and their research work in Spain during the 19th century. After the famous Prussian Alexander von Humboldt traveled through Spain during the first months of 1799, there were numerous German travelers who undertook research travels to both Spain’s mainland and its Balearic and Canary Islands, with either a wider or better defined scientific target. This study provides an overview of these travels, outlining the traveler’s main scientific interests, the regions of Spain that captured more their interest, as well as the evolution of their scientific focus throughout the 19th century. Another topic consists of the relationships and interactions that these scientists set up among themselves and the Spanish scientific community at the time. Moreover, the different travelers’ view of the visited regions, the particularity of the German view, and external influencing factors are briefly analyzed.