The Silk Road is an extraordinary network of trade, cultural and religious routes of about 15000 km of length. For more than 2000 years it has represented the only link between East and West peoples. From the ancient city of Xi’an, the silk production centre, the Silk Road is arrived to the Mediterranean Sea through Russia, Kazakhstan, Tajikistan, Kyrgystan, Uzbekistan, Turkmenistan, Afghanistan, Iran, Iraq, Armenia, Syria, Turkey, Greece and Egypt. The main objective of this contribution is the analysis of the cultural value of this trade route which has favoured the exchange of many products providing relevant social, economic and cultural contacts. The Silk Road, for centuries, has joined East and West peoples. A very topical theme today.