Osteoclasts are specialised cells that work together with osteoblast to keep bone homeostasis. The molecules macrophage colony stimulating factor (CSF-1) and receptor-associate to the nu- clear kappa-beta ligand (RANKL) play a key role in the induction and development of osteoclast (osteoclastogenesis) from granulocyte-macrophage cells. Osteoclastogenesis involve at least 24