Infection by human papilloma virus (hpv) in the mouth is associated with lesions as multifocal epithelial hyperplasia (meh), verruca vulgaris (vv) and condyloma acuminatum (ca). In this study, the effectiveness of clinical diagnosis in lesions caused by hpv in mouth was evaluated, and useful clinical criteria for its diagnosis were proposed. The results suggest, that the clinical evaluation does not allow to differentiate the lesions. Age and the presence of multiple lesions were the clinical variables found for the diagnosis of meh. In the case of vv, female gender and unique pediculate lesions ≤ 7.65mm, and for the ca, age and male gender. Although, these variables might be in- sufficient in some cases, they contribute to the development of a dentistry based on evidence.