The objective of this study was to determine the validity of the markers of severity like APACHE II, score of Ranson and classifi cation of Balthazar in the prediction of mortality in the patients with acute pancreatitis. Historical descriptive observational study of cohorte with base in the registries of the patients with diagnosis of acute pancreatitis from November of 1999 to November of the 2005, that entered the surgical units of intensive care of the Hospital Universitario Clinica San Rafael and Hospital Militar Central. We analyze the information of 57 patients being a mortality of 19,3%, APACHE II in relation to mortality showed an area under the curve