SUMMARY Due to the reduced population size and constrained geographical distribution, Crocodylus intermedius has been considered one of the most threatened crocodiles in the world. Frequency of flooding events as well as human and animal predation reduces the amount of eggs and slows the recovery of its populations. The potential for egg collection along the Cojedes River System (CRS) and their incubation under controlled conditions was evaluated. During the 2009 nesting season 13 nests were found along 20.7km of CRS river bank surveyed. Eight of them were collected for incubation and set in artificial nests away from the river bank; the remaining five were geo-referenced and left in their natural conditions and considered as controls. Hatching success in the five con trol nests was 36.4% (90 hatchlings were produced), while for those transferred it was 53.5% (197 hatchlings). In addition, 24 additional nests were confirmed in the river section surveyed by the presence of hatchling pods during the hatching season; therefore, at least 37 females nested in the river section surveyed. We estimate conservatively that ~50 nests could be collected every year in the entire CRS, which could guarantee, at least, the production of 1200 hatchlings. The collection of eggs and artificial incubation in locations near the main river is a successful strategy and could be implemented as part of a conservation program for the species, in which different sectors of society (fishermen, workers, and farm owners) should be involved.