The identification of functional segments in DNA sequences is one of the more heavily studied fields at the present time. Due to the generation of large volumes of information from genome projects, the usefulness of computational predictions has attracted the attention of the general scientific community. At this point the identification of regulatory sequences has emerged as an important area in the field of genome analysis; however, given the enormous complexity of the transcription regulation process, the problem concerning the prediction of regulatory areas, although promising, has not been completely solved. This paper presents a description of some approaches developed for the identification of promoters and their elements, cis-regulators. The structures of functional and structural signals are also described that are recognition targets for some of these prediction programs as applied to the gene that codes for the subunit, NR1, from the glutamate receptor sensitive to N-methyl-D-aspartate (iGluR-NMDA), which has been an object of study since the nineties.