This article aims to share the results, experiences, and lessons learned in the exercise of strategic forward planning by the University of La Guajira in Colombia, thereby developing the Agenda for Science and Technology Foresight 2004-2014. The study was conceived as a macro-research project for institutional development of basic functions which are well established as 6 strategic dimensions: political and organizational dimensions, academic dimension, socio-economic dimension, scientific and technological dimensions, environmental dimension, and financial dimension. The research process is categorized as a descriptive methodology applying strategic foresight. The collection of information was achieved by the participation of the stakeholders considered to be at the top of the university and to be the social leaders of the departmental environment. Several workshops were held in municipalities with an institutional presence, where we identified accelerating and decelerating factors of the development process. Then after agreeing with experts on 28 modifying factors, we selected 6 variables with the help of structural analysis, thus becoming the hypothesis for the future. These alternative scenarios and wagers were chosen by the Makuira Encantada who then designed a prospective strategic development plan to achieve the desired future image.