Isolated retrograde amnesia is a rare neuropsychological deficit and neuropsychological rehabilitation therapy has not been studied or proposed for these patients. This article documents the case of CE, a 28-year-old female patient, resident in Medellin, Colombia, who suffers remote memory loss after being kidnapped. Neuropsychological assessment and structural neuroimaging studies was performed. Then, a neuropsychological rehabilitation plan focused on semantic memory retrieval was planned and implemented. After the intervention, cognitive and functional improvement was found, with significant increase in mnemonic and neurolinguistic skills, also in understanding of her environment and her performance in daily activities.