We consolidated a preliminary herpetological list based on a rapid field assessment during the dry season (February 2008) in the Inirida fluvial confluence (the meeting point of the Guaviare, Inirida, Atabapo and Orinoco rivers), data on confiscated fauna from regional corporations and a literature review. We identified 62 species, 31 for both Amphibia and Reptilia classes respectively. The Amphibia class is represented by the Anura order with six families, including Hylidae the most diverse (12 sp.), followed by Leptodactylidae (10 sp.). The Reptilia class is comprised of three orders (Crocodylia, Squamata y Testudines), with 12 families. The most diverse families were Colubridae (6 sp.) and Podocnemididae (5 sp.). It is probable that the regional diversity of the herpetofauna of the Inirida confluence is greater than 100 species. Seven species are in some degree of threat, specially, aquatic turtles.