Systemic Lupus Erithematosus (LES) it is a multisystemic disease of unknown etiology, characterized by the production of antibodies that present in susceptible hosts, in whom the probably exists an alteration in lymphocytes homeostasis, and the tolerance associated to an increased apoptotic process correlated to a defect in the removal of the auto - antigens generated. Although it is more frequent in women rather than men, it is important not to forget that in men it is apperance is more severe, which is why themorbi - mortality is higher. Current treatments with corticoids and inmunosupresores achieve disease control in 70 - 80% of cases, but based on a high morbility. Case No one is about a 19 year old patient with a LES diagnosis of more or less 3 years, whose first manifestations of the disease were generalized arthalgias, anemia, widespread edema with changes in renal function and reactivation of the clinicalmanifestations, such as convulsive crisis and high blood pressure.