The treatment of non-ulcer dyspepsia keeps on being a conundrum. In spite of the many treatments that we have to deal with this disease neither has shown a benefit much higher than the placebo. One of the most common types of medication to treat this disease is the proquinetics. Among this class of medications; domperidone which is a dopaminergic antagonist has shown a moderate effect. The porpoise of this systematic review is assessing the existent bibliography over the actual roll of domperidone in the treatment of patients with non-ulcer dyspepsia. After the critical appraisal of the literature that I have done; we can conclude that domperidona is safe and useful in the treatment of non-ulcer dyspepsia, in fact the number needed to treat is only 4.