ImpactU Versión 3.11.2 Última actualización: Interfaz de Usuario: 16/10/2025 Base de Datos: 29/08/2025 Hecho en Colombia
Detección de Helicobacter pylori y caracterización del la región -31 del gen de la Interleucina 1-ß humana en pacientes de una población colombiana con enfermedades gastroduodenales
The aim of this study was to investigate the presence of Helicobacter pylori and interleukin 1-β genotyping (IL-1B -31), to determine the relationship between one polymorphism in the -31 region of interleukin 1-β gene and the severity of the clinical manifestations. Gastric biopsies from 71 patients were submitted to histopathological examination and genotyped by molecular methods (PCR y PCR-RFLP). The results indicated that 97.2% of the patients have alterations in the gastric mucosa, the presence of H. pylori was demonstrated in 44 patients and TT, CT and CC genotypes were detected in 12.7%, 60.6% and 26.8%, respectively. IL-1B genotypes were not associated with the severity of gastric mucosal damage in the studied population.
