Objective: To determine the levels of inflammatory markers in patients with DM1 compared to controls without DM1, and their relationship with lipid profile, metabolic control and duration of diabetes. Materials and Methods: We selected 38 patients from the Endocrinology Service of IAHULA, Merida (n = 13) and Tachira endocrinologist consultations (n = 25) with DM1 without chronic complications of diabetes (Study Group). We selected 40 patients without diabetes mellitus, adjusted for age and sex to patients, who formed the control group. We used a questionnaire covering demographic data and physical examination. Then we calculated the body mass index and laboratory tests in serum were performed: glucose, triglycerides, total cholesterol, LDL-C, HDL-C, HbA1c, C-reactive protein (CRP) and tumour necrosis factor (TNFα). Results: There was no statistical difference between study and control groups regarding age, weight, height and body mass index (BMI). Systolic blood pressure (SBP) was higher in the study group (DM1; p=0.017). HDLC levels were significantly higher in the group of diabetic children (p=0.0001) and there were no significant differences in the other lipid. Levels CRP was not different between groups but showed a significant positive correlation with markers of adiposity (BMI and waist circumference) (p=0.0001), arterial blood pressure (p=0.002) and duration of diabetes (p=0.02). The FNTα was significantly higher in type 1 diabetic patients and showed a strong positive correlation with hyperglycemia (p=0.0001) and weak with SBP (p=0.01). Conclusions: FTNα increased levels in diabetic children and the positive correlations of this factor with glycemia, as well as PCR with adiposity, blood pressure and duration of DM1, suggest a possible relationship between inflammatory markers and DM1, however, follow-up studies are needed to determine its importance.