In this work was identified the physical, compositional and physicochemical properties of Andean Lupin seed (Lupinus mutabilis) grown in the Andes of Narino. The proximal composition analyses were performed to the whole seed, cotyledons and seed coat. In addition, it was determined the content of minerals and their elemental composition. It was established quantitatively the content of alkaloids and its compositional profile. Physical properties were determined such as the size and shape. Physicochemical properties were determined as water holding capacity and pH. The nutritional components of the seed are less with the values reported in the literature, for seeds from elsewhere. It presents a variation in the profile of alkaloids being the alkaloid spartein second major presence. The seed hidratation achieves an increasing of 1.72 times its original size. It can be suggested that protein has hydrophilic affinity as evidenced by the high water retention capacity. The identification of these properties allows recognize the potential use of this natural resource.