1. In the practice of gastroenterology the most frequent type of disease is functional. In organic diseases the existence of emotional problems characterized by depression and/or anxiety are common. Therefore in the therapy of these diseases the use of nontoxic well tolerated psycho-analeptic drugs is justified. 2. A clinical experience using the psycho-analeptic drug niamid, pfizer, on 40 patients reported: 32 functional, 14 irritated colon and 18 digestive neurosis, and 8 organic, 1 gastric ulcer, 2 liver cirrhosis, 1 chronic ulcerative colitis, 3 duodenal ulcer and 1 hepatic coma,. 3. The dose of niamid used was 75 mgs. administered by mouth daily; the majority of the patients have been controlled during nine months; the case of hepatic coma was treated with an intravenous injection of 150 mgs. administered daily. 4. The drug was well tolerated in 32 cases, and in 8 cases there was a slight intolerance manifested by contipation, 6 cases, and headache 2 cases. The effect of the drug was manifested on the 11.2 day after the treatment was started. These responses were essentially: general improvement 94 per cent; improvement of spirits 81 per cent; cooperation 77 per cent; and improvement in the general aspect of the patient 87 per cent. Appetite and weight increased in 22.5 per cent and 29 per cent cases respectively. 5. Two cases of cirrhosis and one of chronic ulcerative colitis notably improved with the combination of niamid and the respective treatment for each disease. 6. The hepatic coma subsequen to a liver cirrhosis was controlled by niamid administered by intravenous infection. 7. In the cases of liver cirrhosis the hepatic tests were normalized during the combined treatment with niamid. 8. Niamid was demostrated to be a non toxic drug; throughout the clinical experience routine laboratory controls and hepatic function tests were normal.