An experiment was carriet out in one of the greenhouses of the National University of Colombia located in Bogota, between 1988 and 1989. The objetive was to evaluate. the resistance to P. infestans of the progenies of 51 crosses (F1 and advanced) that included in their pedigree wild, primitive specias and/or cultivated potatoes. Then after a first cycle of selection the chosen genotypes were evaluated in the field for resistance to the disease, for male fertility and productive potential (Kg/plant). Under greenhouse conditions was found a good resistance to no especific races of P. infestans in the progenies of the simple cross with phureja, that included the wild spicies polyadenium, stolonilferum, iopetalum, avilesii, okadae, and susceptibility in those that had dodsli, abancayense, ambosinum, canasense, gandarillasii, pempesense, marinasense and stenaie« wilds. At tha and of the second cycle of evaluation in the fielcfihere were selected 27 genotypes: 5 of simple crosses, 9 of triple crosses, 2 of multiple crosses that included wild species in their pedigree (avilessi, brachycarpum, stoloniterum, iopetalum, hougasii, acaule) and the other 11 included primitive or advanced genotypes. An excellent productive potential was found in genotypes of interespectific cross of avilesii x phureja, and genotypes of triple eross that ineluded the hougasii or sceute speeies. The male fertility of the evaluated genotypes oseillated from sterility to high fertility.