Los hongos C. albicans y los dermatofitos tienen caracteristicas especiales que les confieren la habilidad de infectar tejido queratinizado. C. albicans es un comensal que en algunas circunstancias y en el hospedero susceptible es capaz de causar infecciones superficiales o sistemicas. Los factores de virulencia de este patogeno oportunista incluyen: su capacidad de adherencia al hospedero, la secrecion de enzimas degradativas, su cambio de morfologia y la formacion de biopeliculas. Los dermatofitos son la causa mas comun de infeccion de la piel, la cual logran infectar por factores de virulencia como la adherencia y la invasion de tejidos queratinizados. Conocer a profundidad los factores de virulencia puede ayudar en la elaboracion de terapias dirigidas y eficaces frente a ellos. A continuacion se presentan una revision de la literatura de los factores de virulencia de C. albicans y los dermatofitos. Abstract C. albicans and dermatophytes have special characteristics that confer them the ability to infect keratinized tissues. C. albicans is part of the human flora but under some circumstances and in susceptible individuals it can cause systemic and superficial infections. Virulence factors of this opportunist include: its capacity to adhere to the host, secretion of degradation enzymes, its ability to change morphologically and to form biofilms. Dermatophytes are the most common cause of skin infection and they can achieve this due to virulence factors such as their ability to adhere and invade keratinized tissues. To know and understand in depth the virulence factors of these fungi might to find further direct therapies in a more efficacious way. We present a literature review about the virulence factors of C. albicans and dermatophytes.