Marine invertebrates are an important component of oceanic biota and a rich source of novel and biologically activecompounds,�suchasanti-bacterial,�anticancer,�anti-inflammatory,� andantioxidantsagents,�amongothers.� In this study we evaluated the antioxidant activity of methanol extracts from marine sponges from the Colombian Caribbean: Amorphinopsis atlantica, Callyspongia vaginalis, Ircinia felix, Lissodendoryx carolinensis, Mycale microsigmatosa, Niphates erecta, and Tedania ignisagainsttheradicalABTS• + cation, using trolox as a reference. Thepreliminarytestsperformed�(100�μg/ml)�showedgoodinhibitionoftheradical�(>�53%)�withextractsfromA. atlantica�(IC50�=�88.26�μg/ml),�M. microsigmatosa�(IC50�=�59.80�μg/ml),�andI. felix�(IC50�=�88.81�μg/ml)�and� low inhibition of the radical (< 33%) to extracts from the other sponge species. Upon evaluating the antioxidant activity of aqueous fractions of dichloromethane obtained from each of the selected methanol extracts, we found that the greatest inhibition of the radical was obtained from the aqueous fraction of A. atlantica, (IC50� =�58.75�μg/ml),� exceeding that exhibited by the methanol extract of this sponge; in addition, the least inhibition was exhibited by the organic fraction of I. felix (IC 50 �=�120.49�μg/ml),�avalueconsiderablegreaterwhencomparedwiththe� respective extract. the results suggest that marine sponges of the Colombian Caribbean are capable of producing substancesthatinhibitthechemicalreactivityoforganicradicalssuchasABTS• + .