Cardiovascular disease is the leading cause of death among women. Its impact on health is not only related to mortality rate because there are a number of women surviving from this disease due to scientific and technical advances in diagnostic procedures and treatment leading to a higher life expectative and high health costs. For this reason is important to implement prevention strategies for diagnosis and treatment of the main cardiovascular risk factors. It is well known that cardiovascular disease has gender differences in presentation, evolution and prognosis that justified the formulation of specific guidelines for women by the American Heart Association which will make easier the early identification and stratification of women at cardiovascular risk according to the main risk factors and the implementation of specific therapeutic intervention. This review will be focus on the main cardiovascular risk factors in post menopausal women and will describe the characteristics findings of coronary heart disease in women and, the prevention strategies of cardiovascular disease.