Hyde’s Nodular Prurigo is a chronic dermathosis characterized by extremely itchy papular and nodular lesions. Concerning it’s treatment, a number of topical, intralesional and systemic medicines, along with cryotherapy and phototherapy have been used, usually in a concomitant way. In spite of the various options, many treatments lack efficacy and there are no standardized protocols. This manuscript’s the presentation of a clinical case concerning a 22-year-old woman with disseminated lesions in an advanced stage in both upper and lower limbs. The patient developed an important (60%) evolution of the clinical picture in little time with the combination of not-so-aggressive dermatological treatments such as cryotherapy and capsaine plus an antidepressant such as trazodone. A short literature review is performed.