Resumen Introduccion: En Pasto Colombia, el cancer colorrectal es una de las principales causas de morbi-mortalidad por cancer. Para contribuir a la prevencion primaria de esta enfermedad es necesario realizar estudios que permitan identificar la poblacion a riesgo y los factores que influyen en su desarrollo. Objetivo: Analizar los habitos de vida que predisponen al desarrollo de CCR en la poblacion de Pasto para contribuir a la toma de decisiones dirigidas a la prevencion y el control de esta enfermedad. Materiales y metodos: Se realizo un estudio observacional analitico con una muestra de 55 casos (CCR+) seleccionados aleatoriamente de la base de datos de Registro Poblacional de Cancer del Municipio de Pasto y pareados con 55 controles (CCR-). Mediante una regresion logistica multivariada se identifico la relacion y fuerza de asociacion entre los habitos de vida (actividad fisica, consumo de alcohol y tabaco) y el desarrollo de CCR, ajustando el modelo por covariables demograficas, socioeconomicas y clinicas. Resultados: En el analisis multivariado se identifico que el consumo diario de alcohol y el consumo diario de cigarrillo presentaron una asociacion estadisticamente significativa con el desarrollo de CCR. Las personas con un consumo alto de alcohol (OR ajustado=5,8 IC95% 1,3-26,7) y un consumo de cigarrillo severo (OR ajustado=9,1 IC95% 1,7-70) tienen mayor probabilidad de desarrollar CCR que los individuos que no beben o fuman respectivamente. Conclusiones: Los hallazgos sugieren que necesario promover campanas de sensibilizacion que permitan dar a conocer, en la poblacion del municipio de Pasto el riesgo a desarrollar CCR causado por inadecuados habitos de vida como el consumo de alcohol y tabaco.Abstract Introduction: In Pasto Colombia, the colorectal cancer is one of the major causes of morbidity and mortality from cancer. To contribute to the primary prevention of this disease, it is necessary to do studies which help to identify the population at risk and the factors that influence its development. Objective: To analyze people’s lifestyles that predispose to the development of colorectal cancer (CRC) in Pasto and so contributing to decision-making for the prevention and control of this disease. Materials and methods: An analytical observational study was conducted with a sample of 55 cases (CRC +) who were randomly selected from the database of Cancer Registry of the Municipality of Pasto and matched with 55 controls (CRC -). The relationship and strength of association between lifestyle (physical activity, alcohol and snuff) and development of CRC was identified by using a multivariate logistic regression and adjusting the model for demographic, socioeconomic and clinical covariates. Results: In the multivariate analysis, it was identified that the daily consumption of alcohol and daily cigarette smoking was a statistically significant association with the development of CRC. People with a high intake of alcohol (adjusted OR = 5.8 95% CI 1.3 to 26.7) and severe cigarette consumption (adjusted OR = 9.1 95% CI 1.7 to 70) are more likely to develop CRC than the individuals who do not drink or smoke respectively. Conclusions: The findings suggest a need to promote awareness campaigns that show the risk of developing CRC caused by improper lifestyle habits such as alcohol and snuff to the population of the municipality of Pasto.