Se e studia ron los a spe c tos c linicos e histopatologicos del carcinoma de celulas escamosas (CCE) en bovinos del Departamento de Cordoba, Colombia. Se realizo un estudio descriptivo, no probabilistico, en bovinos. Se estudiaron 11 bovinos con CCE diagnosticados clinica e histopatologicamente en diferentes explotaciones ganaderas del Departamento de Cordoba, Colombia. Al describir los casos se observaron areas con eritema, edema, descamacion con formacion de costras, apariencia tumoral de consistencia variable, en algunos casos friable y en otros firmes, asi como ulceraciones amplias y profundas en forma de crater, con presencia de exudacion serosanguinolenta. Las lesiones se ubicaron en areas despigmentadas de ojos, dorso, region de la grupa, espalda, vulva y perine de los animales estudiados. Histopatologicamente se observo presencia de islas con facil distincion de perlas corneas rodeadas de celulas tumorales y cordones ramificados delgados de celulas epiteliales neoplasicas con grado variable de diferenciacion escamosa, puentes intercelulares, celulas escamosas organizadas y atipicas con nucleos hipercromaticos y variado numero de celulas en diferentes fases de mitosis. El diagnostico definitivo de la enfermedad se fundamento en las caracteristicas clinicas, diagnostico diferencial y en los hallazgos histopatologicos, siendo concluyentes como metodos de diagnostico del CCE. Este estudio representa el primer reporte de CEE en bovinos en el Departamento de Cordoba, Colombia. Abstract This trial studied, the clinical and histopathological features of squamous cell carcinoma (SCC) in cattle of Cordoba Department, Colombia. The type of study performed was descriptive and non-probability, in convenience animals. Eleven animals diagnosed with SCC were clinically and histopathologically studied. Clinical cases showed areas of erythema, edema, crusting desquamative surface of variability in consistency. Tumors appearances in some cases were friable to hard with a widened deep crater-like ulceration with serohemorrhagic exudates. Lesions were locally extensive with depigmentation around the eyes, back, buttocks, vulva and perineum of the animals studied. Histopathology showed presence of conspicuous islands whorls of keratin pearls of tumor cells with thin ramified strands of neoplastic epithelial cells with varying degrees of squamous differentiation, intercellular bridges network and atypical squamous cells with hyperchromatic nuclei and high mitotic index. The final diagnosis of the SCC was based on clinical features, differential neoplastic diagnosis and histopathological findings as being conclusive enough diagnostic methods. This study becomes the first report study of this disease in cattle in the Department of Cordoba, Colombia.