This paper shows the key factors that influence the development of innovation in Colombian companies of the departments of Antioquia, Quindio, Risaralda and Santander. Taking as input the innovative profile of the methodological tool, developed by the research group in “Policy and Management of Technology” from The Pontificia Bolivariana University: “Technology Management Methodology for Project” (MGT), applied to 176 companies. This approach was conducted through a series of tests of hypotheses focused on measuring variables like, “diffusion of innovation”, “know-how”, “competitive technical intelligence”, “employees with technology training” and “experimental development budget for R & D + I”, among other. According to these approaches, the states of the innovation, key factors to the analyzed firms in each region, were validated. Statistical models, critical z and percentage distribution, were used to validate the hypotheses, by means of which it was possible to identify weak key factors and opportunities in the various departments analyzed.