Changes experienced by people diagnosed with Chronic Non-Communicable Diseases (NCDs), at the individual, familial, or social levels show the importance of psychological interventions based on the cognitive-behavioral model. This article reviews literature showing the effectiveness of this model in facilitating adjustments in lifestyle, generating greater compliance with the treatment, minimizing risks of relapse, and maintaining the patients’ and their families’ quality of life level. The conclusion is that it is essential for psychological interventions to be carried out with quality, equality, timeliness, and pertinence, in order to reduce the instrumental, temporal, and professional costs of treating NCDs in the medium term.