Objective: To describe the handling of Metered-Dose inhaler (MDI) in adults of the pneu-mology medical consultation located in Atlantico country (Colombia), 2013. Materials and Methods: We conducted a cross-sectional descriptive study which es-timated 131 adults patients that were using MDIs (pressurized inhaler) with or without a holding chamber and were attending into two health institutions located in Atlantico County, Colombia. We designed and applied a questionnaire that contained a checklist that was allowed for the evaluation of the technique. Results: Mean age was 44.75 years (SD +/-: 17.77). The success rate in the use of the technique was low, 1.52% (2) was perfect, 24.43% (32) was adequate and 74.05% (97) inadequate. Out of 131 patients, 105 used inhalers without holding chamber and 26 with holding chamber. Conclusions: There are weaknesses in the Handling of Metered-Dose inhaler (MDI). 74.05% of patients misused the MDI. The technique steps that are often wrongly executed by patients were: not exhale the residual volume, not start breathing when activating the canister, not inhale slowly and deeply, not retain the medication for 10 seconds and not hold the breath, not wait 30 seconds in between puffs and not shake again the inhaler be-fore shooting it for a second time. It needs to implement education programs that involve professional nursing staff.