Aim: To compare the efficacy of plastic stents in the treatment of distal and proximal stricture of biliary tract neoplasm’s. Methods: From January 2002 to February 2009, 70 patients (37 males, 33 females) with non surgically resectable malignant biliary obstruction who received plastic stent implantation were reviewed retrospectively. The stents were inserted by endoscopy. The endoscopist implants one or more stents if he considers this necessary. The end points of the study were stent occlusion and patient death. Results: The mean time of stent patency was 81 ± 75 days in the group of proximal stricture (group 1) and 130 ± 68 days in the group of distal stricture (group 2), (p 0.40, with CI 95% 0.47-1.37). The mean survival time was 126 days in group 1 and 159 days in group 2. There was not a significant difference between the two groups. Conclusion: Plastic stent implantation is a feasible, palliative method for unresectable malignant biliary obstruction. The overall survival and obstruction with the use of plastic stent in patients with distal stenoses compared with proximal obstruction was not significantly different in our study.