The history of this syndrome is an initially incomprehensible correlation of a pro-thrombotic state and in vitro detection of a bleeding tendency called lupus anticoagulant. Graham R. V. Hughes from St. Thomas Hospital in 1982 presented at the Heberden Round of the British Society of Rheumatology to a Sixteen-year-old patient with positive anti-cardiolipin antibodies and negative serology for lupus, who Today, there are no clinical or serological data for lupus. This patient had the criteria for this syndrome. In 1983 Hughes described the different passages mentioned above in the Prosser-White Oration from the British Society of Dermatology and in the British Medical Journal published its classic article on a group of patients with lupus, arterial and venous thrombosis, repeat abortions and lupus anticoagulant1,2. Graham Hughes's description is the product of careful clinical observations that combined with serious studies scientists and with laboratory-based documentation. With Hughes's description in 1983, intertwine the laboratory with the description of Wassermann3 in 1906, when describing a method to detect syphilis, and from that date a series of hematological alterations were discovered, which initially not associated with lupus, but intuition and the fact of being described in patients with lupus related them to this disease. We will now describe how these findings were made. In this way managed to break the paradigm that lupus in the bed vascular only produces vasculitis; later, in addition to antiphospholipid syndrome, the premature atherosclerosis.