Summary We describe the clinical case of a 90 year old female patient presenting weight loss and anemia. Physical examination detected an abdominal mass in the epigastrium. An abdominal scan revealed wall thickening at the transverse colon. When a colonoscopy was performed an in fi ltrating mass discovered. Biopsies diagnosed colonic tuberculosis. We present a literature review of digestive TBC, emphasizing colonic tuberculosis. Key words Tuberculosis, Colon, Digestive TBC. PRESENTATION Th e following is about a 90 year-old patient referred for gas-troenterological examination because of anorexia, asthenia and weight loss. She did not present dysphagia, post-pran-dial plenitude, obvious abdominal pain, diarrhea, fever or digestive bleeding. Her background revealed a prior ascariasis for which she had received treatment in 2007. She had also been treated for two urinary infections (E. Coli > 100000 col.). She had occasionally presented episodes of coughing which had been interpreted as bronchial hyperactivity. Her cough had improved with symptomatic medical treatment. She was receiving treatment for arterial hypertension, lipid lowering medications, and occasionally took non-steroid anti -infl ammatory drugs for osteoarthritis.Th e physical examination found a weak and senile, but conscious patient with apparent nutritional deterioration. TA 120x90 FC: 72 x min. Weight 39.5 kg (1 year before she weighed 46.5 kg). Cardiopulmonary auscultation revealed only a discrete decrease in vesicular murmur. Abdominal palpation found a depressible soft abdomen and a hard, mobile, painless, intra-abdominal mass located between the epigastrium and the mesogastrium. It was approxima-tely 5 cm. in diameter. A check of results of routine lab tests performed periodi-cally during the previous 18 months revealed a CBC with mild progressive anemia (initial 01/07: Hcto 38 - Hb 12.8 gr. up to Hcto. 32 – Hb 11.0 gr. in 06/08), and normal leu-cocytes and platelets. However, the VSG was repeatedly ele-vated (45mm/hour). Glycemia, ALT, AST, DHL and TSH were normal. Creatine oscillated between 1.2 – 1.8 mg%. Proteinemia was 6.5 g., and albumen was 4.3 g. Protein electrophoresis and alkaline phosphatase were normal. An abdominal ultrasound showed colelithiasis. An abdominal TAC was requested (fi gures 1 and 2) which showed a thickening of the transverse colon walls with extensive colonic diverticulosis. It suggested the pos-sibility of diverticulosis in the resolution phase. No other intestinal or extra-digestive lesions were found. She was referred for a colonoscopy which was performed under sedation. An ulcerated lesion, 50% infi ltrated with stenosis, was found in the transverse colon towards the splenic angle (fi gures 4 and 5). It extended for approxima-tely 5 cm. blocking the path of the endoscope toward the right hemicolon. Near and imme diately next to the discrete lesion was a pedicure polyp of 15 mm. in diameter with an adenoma appearance (fi gure 3). Th e procedure had to be suspended immediately aft er obtaining a sample for biopsy because the patient experienced cardiac arrhythmia and